化合物详情

Ingestion Exposure: Sore throat. Burns in mouth and throat. Abdominal pain. Vomiting. Shock or collapse.

PRETREATMENT OF MICE WITH IP INJECTED GLUTATHIONE OXIDIZED 0.58 MICROMOLE/KG PROTECTED THEM AGAINST A SUBSEQUENT LETHAL CHALLENGE WITH SODIUM SULFIDE 0.83 MICROMOLE/KG.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Serious local effects by all routes of exposure.

Man: severe toxic effects: 200 ppm = 280 mg/cu m 1 min; symptoms of illness: 50 ppm = 70 mg/cu m unsatisfactory: 20 ppm = 28 mg/cu m lethal: 600 ppm, 30 min 800 ppm, immediately.

LC50 Rat inhalation 1500 mg/cu m/14 min. /Hydrogen sulfide/

Administration of sodium hydrosulfide, an alkali salt of hydrogen sulfide at doses of 10 and 30 mg/kg, corresponding to sublethal and lethal doses (0.66 and 2.0 LD50) resulted in significant increases in regional catecholamine levels of the rat brain only after the dose of 2.0 LD50 of sodium hydrosulfide. Whereas the cortex and the cerebellum showed little or no change in catecholamine content, the hippocampus, striatum and brainstem all showed increases in noradrenaline and adrenaline. Additional analysis also showed that brainstem dopamine and 5-hydroxytryptamine levels (5-HT) increased as well. In vitro testing of sulfide for inhibition of monoamine oxidase activity showed the anion to be inhibitory with an IC50 of 39.1 + or - 3.6 uM. Inhibition of monoamine oxidase activity ex vivo...

For advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: To keep open, "minimal flow rate"/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of pulmonary edema. Consider vasopressors to treat hypotension without signs of hypovolemia ... . Treat seizures with diazepam (Valium) ... . In severe cases use amyl nitrite and sodium nitrite .....