化合物详情

Thromboembolism, thrombotic and thrombophlebitic events (eg, sagittal sinus thrombosis, stroke), pseudotumor cerebri (benign intracranial hypertension), peliosis hepatitis, benign hepatic adenoma have been reported with danazol use. Elevated concentrations of hepatic enzymes (eg, alkaline phosphatase, AST, ALT) and jaundice have been reported with doses of more than 400 mg daily. Danazol treatment may also cause decreased HDL and increased LDL. Danazol causes possible interference with laboratory measurement of androgens, for example, testosterone. Moreover, danazol is reported to be a CYP3A4 inhibitor; its concurrent use with statins has been reported to cause rhabdomyolysis.

Toxicity discussion generally revolves around the virilizing effects of danazol in females. Symptoms of overdose may include yellowing of the skin and eyes, abdominal pain, and dark urine. There is no antidote for danazol.

References: DOI:10.1016/j.drudis.2019.09.022

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