化合物详情

CAS18820-29-6

分子式MnS

分子量87.01 g/mol g/mol

危化品

Manganese(II) sulfide is a sulfide of manganese. It occurs in nature as the mineral alabandite. Manganese is a naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in its pure form, but is found in many types of rocks in combination with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay healthy, as manganese ions act as cofactors for a number of enzymes. (L228, L229, L237)

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Treatment

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Effect Level

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Lethal Dose

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Health Effects

Adverse Effects

Neurotoxin - Parkinsonism

Exposure Routes

Oral (L228); inhalation (L228)

Toxicity Summary

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant...

Minimum Risk Level

Chronic Inhalation: 0.0003 mg/m3 (L134)

Lethal Concentration

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Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Reference and Risk Values

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