化合物详情

EC50 Tubifex tubifex (Tubificid worm; intoxication, immobilization) 6.7 ug/L/96 hr (95% confidence interval: 5.1-7.2 ug/L); renewal /Technical product/

ATMOSPHERIC FATE: Osmium tetroxide is a volatile osmium compound(1). It would not be expected to persist in the environment(SRC), since osmium tetroxide is readily reduced by organic matter(1).

UNCLAIMED OSMIUM TETROXIDE FROM COPPER SMELTERS THAT REACHES WASTEWATER STREAMS IS PROBABLY RAPIDLY REDUCED BY ORGANIC MATTER TO NONTOXIC OSMIUM DIOXIDE OR OS METAL, WHICH WOULD SETTLE OUT IN THE SEDIMENT OF WATER COURSE.

UNCLAIMED OSMIUM TETROXIDE FROM COPPER SMELTERS THAT REACHES WASTEWATER STREAMS IS PROBABLY RAPIDLY REDUCED BY ORGANIC MATTER TO NONTOXIC OSMIUM DIOXIDE OR OS METAL, WHICH WOULD SETTLE OUT IN THE SEDIMENT OF WATERCOURSE.

This substance may be hazardous to the environment. Special attention should be given to crustacea.

Osmium tetroxide is the most industrially important osmium compound(1); its use as an oxidation catalyst(1) may result in the release of osmium compounds through various waste streams(SRC).

... EXPOSURES TO OSMIUM OCCUR /SRP: IN EM PATHOLOGY LAB PERSONNEL AND/ NEAR OPERATIONS OF ROASTING, SMELTING, & REFINING OF CU CONCENTRATES AS SUBLIMED OSO4... PROBABLY THE GREATEST LOSS OF OSO4 WOULD OCCUR IN THE SMELTING & REFINING PROCESSES, FROM WHICH NONE OF THE PRESENT CONTROL DEVICES WOULD RECOVER THE VAPORIZED OSO4.

irritation eyes, respiratory system; lacrimation (discharge of tears), visual disturbance; conjunctivitis; headache; cough, dyspnea (breathing difficulty); dermatitis

Eyes, skin, respiratory system

LCLo (rat) = 40 ppm/4H

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

inhalation, ingestion, skin and/or eye contact

The acute toxicity of osmium tetroxide is high, and it is a severe irritant of the eyes and respiratory tract. Exposure to osmium tetroxide vapor can damage the cornea of the eye. Irritation is generally the initial symptom of exposure to low concentrations of osmium tetroxide vapor, and lacrimation, a gritty feeling in the eyes, and the appearance of rings around lights may also be noted. In most cases, recovery occurs in a few days. Concentrations of vapor that do not cause immediate irritation can have an insidious cumulative effect; symptoms may not be noted until several hours after exposure. Contact of the eyes with concentrated solutions of this substance can cause severe damage and possible blindness. Inhalation can cause headache, coughing, dizziness, lung damage, and difficult...

Max concentration said to be tolerated without after-effects is 0.1 ppm in air for 1 1/2 hr or 0.0001 ppm for 6 hr.

LD50 Mouse ip 13.5 mg/kg

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/