化合物详情

CAS22832-87-7

分子式C18H14Cl4N2O · HNO3

分子量479.14 g/mol g/mol

危化品

HIV/AIDS and Opportunistic Infection Drugs | Miconazole is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of mucocutaneouscandidiasis, including

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.

Lethal Dose

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Toxicity Data

LD50: 3800 mg/kg (Oral, Mouse) (A308) LD50: 3 gm/kg (Oral, Rat) (A308)

Exposure Routes

Topical

Toxicity Summary

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).