化合物详情

CAS23541-50-6

分子式C27H29NO10 · HCl

分子量563.98 g/mol g/mol

危化品

Daunorubicin Hydrochloride can cause developmental toxicity according to state or federal government labeling requirements.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

symptoms include gastrointestinal disturbances. (A723)

Treatment

Infuse 10 to 20 mL/kg isotonic fluid. If hypotension persists, administer dopamine. (A704)

Toxicity Data

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Health Effects

Antibiotic resistance. Toxic manifestations of Daunorubicin include bone marrow depression, stomatitis, alopecia, gastrointestinal disturbances, and dermatological manifestations. Cardiac toxicity is a pecular effect. (A723)

Exposure Routes

Intravenous

Toxicity Summary

Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Carcinogen Classification

2B, possibly carcinogenic to humans. (L135)

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation

◉ Effects on Lactation and Breastmilk