化合物详情

collection=toxvaldb&kind=^LD$

LD50: 462 mg/kg (Oral, Mouse) (A308) LD50: 462 mg/kg (Oral, Rat) (A308) LD50: 668 mg/kg (Oral, Guinea pig) (A308) LD50: >160 mg/kg (Oral, Dog) (A308)

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

No indication of carcinogenicity to humans (not listed by IARC).

◉ Effects on Lactation and Breastmilk