化合物详情

OCCURS AS AN ALTERATION PRODUCT OF PERICLASE IN SERPENTINE AND MARBLE AND IN CHLORITE AND DOLOMITE SCHISTS

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ALKALINIZATION OF URINE CAN DECR EXCRETION OF VARIOUS WEAKLY BASIC DRUGS (EG QUINIDINE). MG(OH2) INCR ABSORPTION OF WARFARIN IN MAN & DECR ABSORPTION OF BARBITURATES IN RATS.

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Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications

/HUMAN EXPOSURE STUDIES/ PROLONGED USE OF MG(OH)2 MAY RARELY CAUSE RECTAL STONES COMPOSED OF MGCO3 & MG(OH)2.

LD50 Rat intraperitoneal 2780 mg/kg

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/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Preventive effect of magnesium hydroxide on carcinogen-induced, large bowel carcinogenesis was examined in three experiments using F344 rats. Experiment I: Rats received dietary administration of magnesium hydroxide at concentrations of 500 or 1,000 ppm after treatment with methylazoxymethanol (MAM) acetate (25 mg/kg, 3 times). These rats had a lower incidence of large bowel neoplasms than animals given MAM acetate alone. Reduction of the tumor incidence was especially significant at a dose of 500 ppm. Experiment II: Rats given magnesium hydroxide (250, 500, or 1,000 ppm) together with 1,2-dimethylhydrazine (DMH) (20 mg/kg, 10 times) showed a lower multiplicity of large bowel tumors than those given DMH alone. Experiment III: The...

A study in 40 pairs of matched healthy women with vaginally delivered singleton pregnancies, outcome endpoints were compared in those receiving continuous oral magnesium aspartate HCl supplementation mean dose of 459 mg daily (range 365 to 729 mg of magnesium daily) for at least 4 weeks before delivery versus non-supplemented controls. In the magnesium group, significantly fewer women could breastfeed their infants exclusively at discharge (63% vs 80%).