化合物详情

CAS27686-84-6

分子式C18H22O4

分子量302.36 g/mol g/mol

非危品

Masoprocol is the meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. It has a role as a metabolite, a hypoglycemic agent, an antineoplastic agent and a lipoxygenase inhibitor.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing.

Exposure Routes

Less than 1%-2% is absorbed through the skin over a 4-day period following application.

Toxicity Summary

Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known.

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).