化合物详情

LC50 Oryzias latipes (Medaka; average body weight= 0.32 g) >500 ppm/48 hr /Conditions of bioassay not specified in source examined/

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene bis(tetrabromophthalimide), which has an estimated vapor pressure of 2.5X10-22 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase ethylene bis(tetrabromophthalimide) may be removed from the air by wet and dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for ethylene bis(tetrabromophthalimide) can be estimated to be 8X10+5(SRC). According to a classification scheme(2), this estimated Koc value suggests that ethylene bis(tetrabromophthalimide) is expected to be immobile in soil.

Ethylene bis(tetrabromophthalimide), present at 100 mg/L, reached 0% of its theoretical BOD in 28 days at 25 °C using an activated sludge inoculum collected in Japan at 30 mg/L and the Japanese MITI test(1). Aniline was used as a control and degraded 67% after 7 days(1).

UNREVIEWED | An estimated BCF of 9 was calculated for ethylene bis(tetrabromophthalimide)(SRC), using an estimated log Kow of 9.8(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low, as would be expected given the size of this molecule and its very low estimated water solublilty of 3.0X10-9 mg/L(4).

The Henry's Law constant for ethylene bis(tetrabromophthalimide) is estimated as 3.6X10-21 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that ethylene bis(tetrabromophthalimide is expected to be essentially nonvolatile from water surfaces(2). Ethylene bis(tetrabromophthalimide)'s Henry's Law constant indicates that volatilization from moist soil surfaces is not expected(SRC). Ethylene bis(tetrabromophthalimide) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.5X10-22 mm Hg(SRC), determined from a fragment constant method(3).

Ethylene bis(tetrabromophthalimide) is expected to undergo hydrolysis in the environment due to the presence of amide groups; hydrolysis of amides results in the formation of a carboxylic acid and an amine(1).

Ethylene bis(tetrabromophthalimide)'s production and use as a flame retardant in electrical and electronics components, wire and cable insulation, switches, and conductors(1) may result in its release to the environment through various waste streams(SRC).

Occupational exposure to ethylene bis(tetrabromophthalimide) may occur through inhalation and dermal contact with this compound at workplaces where ethylene bis(tetrabromophthalimide) is produced or used(SRC). Occupational exposure would be expected to be minimal(SRC), since ethylene bis(tetrabromophthalimide) is manufactured in a closed system(1).

Ethylene bis(tetrabromophthalimide)'s production and use as a flame retardant in electrical and electronics components, wire and cable insulation, switches, and conductors may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 2.5X10-22 mm Hg at 25 °C indicates ethylene bis(tetrabromophthalimide) will exist solely in the particulate phase in the ambient atmosphere. Particulate-phase ethylene bis(tetrabromophthalimide) will be removed from the atmosphere by wet and dry deposition. If released to soil, ethylene bis(tetrabromophthalimide) is expected to have no mobility based upon an estimated Koc of 8.0X10+5. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimate...

LC (rat) > 203,000 mg/m3/1h

LC50 Rat inhalation >203 mg/L/1 hr

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/