化合物详情

Some people have a contact allergy to imidazolidinyl urea, causing dermatitis. (L1894)

LC50 (rat) > 5,000 mg/m3/1hr

Imidazolidinyl urea releases formaldehyde, a known human carcinogen. It may also react to produce nitrosamines, which are believed to be carcinogenic. (L962, L1890, L1894)

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Oral (L962); inhalation (L962); dermal (L962)

Imidazolidinyl urea is a formaldehyde releaser. It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowing the unmetabolized intact molecule to exert its effects. Formaldehyde is known to form cross links between protein and DNA and undergo metabolic incorporation into macromolecules (DNA, RNA, and proteins). Imidazolidinyl urea is also a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts a...

1, carcinogenic to humans (for formaldehyde). (L135)