化合物详情

Pesticide Ecotoxicity Data from EPA: 10

EC50; Species: Daphnia magna (Water Flea) age <24 hr; immobilization; Conditions: freshwater, renewal; Concentration: 15000 ug/L for 48 hr (95% confidence interval: 12000-18000 ug/L) /75% purity formulation/

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetrakis(hydroxymethyl)phosphonium sulfate, which has an estimated vapor pressure of 8.1 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetrakis(hydroxymethyl)phosphonium sulfate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tetrakis(hydroxymethyl)phosphonium sulfate does not contain chromophores that absorb at wa...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tetrakis(hydroxymethyl)phosphonium sulfate can be estimated to be 140(SRC). According to a classification scheme(2), this estimated Koc value suggests that tetrakis(hydroxymethyl)phosphonium sulfate is expected to have high mobility in soil.

An estimated BCF of 3 was calculated in fish for tetrakis(hydroxymethyl)phosphonium sulfate, using an estimated log Kow of -20.39(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for tetrakis(hydroxymethyl)phosphonium sulfate is estimated as 1.7X10-23 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tetrakis(hydroxymethyl)phosphonium sulfate is expected to be essentially nonvolatile from water and moist soil surfaces(2). Tetrakis(hydroxymethyl)phosphonium sulfate is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.1 mm Hg(SRC), determined from a fragment constant method(3).

The rate constant for the vapor-phase reaction of tetrakis(hydroxymethyl)phosphonium sulfate with photochemically-produced hydroxyl radicals has been estimated as 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tetrakis(hydroxymethyl)phosphonium sulfate is expected to undergo hydrolysis in the environment due to the presence of functional groups that hydrolyze under environmental conditions(2). Tetrakis(hydroxymethyl)phosphonium sulfate does not contain chromophores that absorb at wavelengths >290 nm(2), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Tetrakis(hydroxymethyl)phosphonium sulfate's production and use as a textile crease and flame retardant(1) may result in its release to the environment through various waste streams(SRC). Its use as a biocide in hydrfracking(2) will result in its direct release to the environment(SRC).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tetrakis(hydroxymethyl)phosphonium sulfate is 1 to 99; the data may be greatly underestimated(1).

Tetrakis(hydroxymethyl)phosphonium sulfate's production and use as a textile crease and flame retardant may result in its release to the environment through various waste streams. Its use as a biocide in hydrofracking will result in its direct release to the environment. If released to air, an estimated vapor pressure of 8.1 mm Hg at 25 °C indicates tetrakis(hydroxymethyl)phosphonium sulfate will exist solely as a vapor in the atmosphere. Vapor-phase tetrakis(hydroxymethyl)phosphonium sulfate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4 hours. Tetrakis(hydroxymethyl)phosphonium sulfate does not contain chromophores that absorb at wavelengths >290 nm, and therefore is not expect...

LC50 (Rat) = 5.5 mg/l/4 hr

ACGIH Carcinogen - Not Classifiable.

Summary: Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenicity of THPS in either sex of F344/N rats or B6C3F1 mice given 5 or 10 mg/kg. There was no evidence of carcinogenicity of THPC in either sex of F344/N rats given 3.75 or 7.5 mg/kg, in male B6C3F1 mice given 7.5 or 15 mg/kg, or in female B6C3F1 mice given 15 or 30 mg/kg.

LC50 Rat inhalation 5.5 mg/L 4 hr

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ During 90 day gavage studies, hepatocyte vacuolar degeneration was seen in rats and mice receiving tetrakis(hydroxymethyl)phosphonium sulfate or chloride.

A4; Not classifiable as a human carcinogen.

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...