一键配货
化合物详情
CAS62666-20-0
分子式C17H16ClFN2O2
分子量334.77 g/mol g/mol
非危品
Progabide is a diarylmethane.
科学粮草官-词典编辑部，修订于：2026-07-06
Toxicity
ToxicityHealth Effects
May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
Exposure Routes
Well absorbed with a bioavailability of 60%
Toxicity Summary
Progabide binds to both GABA<sub>A</sub> and GABA<sub>B</sub> receptors located on the terminals of primary afferent fibers. Binding to GABA<sub>A</sub> results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABA<sub>B</sub> receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters.
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
