化合物详情

CAS64228-79-1

分子式C53H72N2O12

分子量929.16 g/mol

非危品

Atracurium is a diester compound consisting of pentane-1,5-diol with both hydroxyls bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium ion and a diester.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Adverse Effects

* Ringer lactate: Ringer lactate should not be used as a diluent, as atracurium degrades more rapidly in this solution than in a 0.9% sodium chloride solution.

Toxicity Summary

The primary focus in managing an atracurium overdose is ensuring proper airway and ventilation. Emergency medicine physicians maintain manual or mechanical ventilation when necessary. Peripheral nerve stimulation is used to monitor neuromuscular block recovery. Recovery can be enhanced with anticholinesterase agents like neostigmine, edrophonium, or pyridostigmine combined with anticholinergic drugs such as atropine or glycopyrrolate. If cardiovascular support is needed, fluids and vasopressors should be administered. Critical care physicians should closely monitor the patient's hemodynamic status and respiratory function. Due to the potential for prolonged recovery, intensive care support is provided until the patient stabilizes and fully recovers from the neuromuscular block. Lethal s...

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2019.09.022

Effects During Pregnancy and Lactation

◉ Effects on Lactation and Breastmilk