化合物详情

CAS67747-09-5

分子式C15H16Cl3N3O2

分子量376.67 g/mol g/mol

危化品

Prochloraz is a member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables. It has a role as a xenobiotic, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor, an environmental contaminant and an antifungal agrochemical. It is a member of imidazoles, a trichlorobenzene, an aromatic ether, a member of ureas, an amide fungicide, a conazole fungicide and an imidazole fungicide.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Cancer Sites

Hepatic

Effect Level

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Target Organs

Hepatic

Lethal Dose

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Toxicity Data

LD50: 1204 mg/kg (oral; rat) (L2082); LD50: >2000 mg/kg (dermal, rat) (L2082); LD50: >2.41 mg/l (inhalation, rat) (L2082)

Health Effects

Suspected endocrine disruptor (A15203).

Exposure Routes

Oral (L2083)

Screening Level

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Toxicity Summary

Prochloraz acts in vitro as a an aromatase inhibitor, aryl hydrocarbon receptor agonist, androgen receptor antagonist, and estrogen receptor antagonist. (A15203)

Effect Concentration

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Lethal Concentration

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RAIS Toxicity Values

Oral Slope Factor Reference: IRIS Current

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Reference and Risk Values

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1 or Cancer Risk Level 1E-06

Fraction of Contaminant Absorbed Dermally from Soil: 0.1

Hazard Quotient Level 3 or Cancer Risk Level 1E-04

Fraction of Contaminant Absorbed Dermally from Soil: 0.1