二苯基二硒

短期高浓度硒口服暴露可能导致恶心、呕吐和腹泻。短时间暴露于高浓度元素硒或二氧化硒空气中可导致呼吸道刺激、支气管炎、呼吸困难和胃痛。对这些空气形式的长期暴露可导致呼吸道刺激、支气管痉挛和咳嗽。(L619)

长期高浓度硒化合物口服暴露可导致一种称为硒中毒的疾病。硒中毒的主要症状是脱发、指甲脆性和神经系统异常（如四肢麻木和其他异常感觉）。动物研究表明，硒也可能影响精子产生和女性生殖周期。(L619)

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage...

3，对人致癌性无法分类。(L135)

慢性口服：0.005 mg/kg/天 (L134)

口服(L619)；吸入(L619)；皮肤接触(L619)