化合物详情

CAS70059-30-2

分子式C10H16N6S.HCl

分子量288.8 g/mol

非危品

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

Symptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.

Treatment

The usual measures to remove unabsorbed material from the gastrointestinal tract, clinical monitoring and supportive therapy should be employed. (L1712)

Exposure Routes

Oral, rapid 60-70%

Toxicity Summary

Cimetidine binds to an H<sub>2</sub>-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

Carcinogen Classification

3, not classifiable as to its carcinogenicity to humans. (L135)