一键配货
化合物详情
CAS79307-93-0
分子式C22H24ClN3O·HCl
分子量418.36 g/mol g/mol
危化品
Azelastine hydrochloride is the hydrochloride salt of azelastine. It has a role as a bronchodilator agent, a H1-receptor antagonist, an anti-asthmatic drug, a platelet aggregation inhibitor, an anti-allergic agent and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It contains an azelastine.
科学粮草官-词典编辑部，修订于：2026-07-06
Toxicity
ToxicityExposure Routes
Absorption of azelastine following ocular administration was relatively low. Systemic bioavailability is approximately 40% after nasal administration.
Toxicity Summary
Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Effects During Pregnancy and Lactation
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
