化合物详情

CAS85509-19-9

分子式C16H15F2N3Si

分子量315.39 g/mol g/mol

危化品

Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor, an environmental contaminant and an antifungal agrochemical. It is an organosilicon compound, a member of triazoles, a member of monofluorobenzenes, a conazole fungicide and a triazole fungicide.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

EPA Ecotoxicity

Pesticide Ecotoxicity Data from EPA: 3

Symptoms

Symptoms include weight loss, weakness, lethargy, alopecia and diarrhoea. At higher dose, prostration, salivation, laboured breathing, convulsions, and loss of righting reflex would be expected. Flusilazole can also cause mild erythema at the site of application.

Effect Level

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Target Organs

Hepatic

Lethal Dose

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Toxicity Data

LD50 (rat, oral) =1110 mg/kg (m) LD50 (rat, dermal) >2000 mg/kg

Health Effects

Flusilazole can cause testicular Leydig-cell tumours and bladder tumours in rats and hepatocellular tumours in mouse. An increased gestation length and increased placental weight have been found in the reproductive toxicity studies.

Screening Level

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Toxicity Summary

Flusilazole has a dose-related inhibition of serum testosterone and estradiol concentrations in rats. This inhibition of testosterone and estradiol biosynthesis may disrupt the hypothalamus–pituitary–testis axis, resulting in overstimulation of the testicular endocrine tissues and increase the risk of Leydig-cell tumours.

Lethal Concentration

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RAIS Toxicity Values

Oral Chronic Reference Dose Reference: OPP

Carcinogen Classification

Not listed by IARC.

Reference and Risk Values

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1 or Cancer Risk Level 1E-06

Fraction of Contaminant Absorbed Dermally from Soil: 0.1

Hazard Quotient Level 3 or Cancer Risk Level 1E-04

Fraction of Contaminant Absorbed Dermally from Soil: 0.1