化合物详情

Pesticide Ecotoxicity Data from EPA: 15

LD50 Bee oral & contact >0.1 mg/bee

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexaflumuron, which has a vapor pressure of 4.43X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere(SRC). Vapor-phase hexaflumuron is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18.3 hrs(SRC), calculated from its rate constant of 21X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase hexaflumuron may be removed from the air by wet and dry deposition(SRC). Based on aqueous photolysis studies(2), hexaflumuron has the potential for direct photolysis(SRC).

Hexaflumuron is strongly adsorbed on a wide range of soils(1,4). The Koc of hexaflumuron is estimated as 29,300(SRC), using a log Kow of 5.68(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that hexaflumuron is expected to be immobile in soil(SRC). Soil Kd (desorption constants) values ranged from 147 to 1,326(4) and soil Kom values ranged from 3,096 to 41,170(1).

ANAEROBIC: Analysis of the anaerobic soils showed the presence of 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline as the major metabolite (8-18% of applied activity), with an unknown metabolite of greater polarity than any of the reference standards observed at levels up to 5% of applied radioactivity(1). Half-lives of (14C-aniline)hexaflumuron at 25 °C under anaerobic conditions were in the range 40-64 days(1).

An estimated BCF of 4,700 was calculated for hexaflumuron(SRC), using a log Kow of 5.68(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC).

The Henry's Law constant for hexaflumuron is estimated as 1.0X10-5 atm-cu m/mole(SRC) derived from its vapor pressure, 4.43X10-7 mm Hg(1), and water solubility, 0.027 mg/l(1). This Henry's Law constant indicates that hexaflumuron is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.2 hrs(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 8.5 days(SRC). Hexaflumuron's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). However, volatilization from moist soil and water surfaces is expected to be attenuated b...

The rate constant for the vapor-phase reaction of hexaflumuron with photochemically-produced hydroxyl radicals has been estimated as 21X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18.3 hrs at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Hexaflumuron is hydrolytically stable in sterile buffers at pH 5.0, is slowly degraded at pH 7.0 (6% breakdown in 33 days) and is more rapidly degraded at pH 9.0 (approx 60% breakdown in 33 days)(2). Hydrolysis at pH 9.0 proceeds by 2 separate routes, with the more facile producing 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenylurea and 2,6-difluorobenzoic acid, and the slower producing 3,5-dicloro-4-(1,1,2,2-tetrafluoroethoxy)phenylurea an...

/AQUATIC SPECIES/ Hexaflumuron, an insect growth regulator (IGR), was found to be nonlethal to four species of larvivorous fish, Poecilia reticulata, Gambusia affinis, Aplocheilus blochii and Tilapia mossambica at | 1.0 mg/l. These species were found to be tolerant with higher LD50 values ranging from 2.21-3.097 mg/l. Absolute survival (100%) was observed in all the four species at 1.0 mg/l for more than 8 days. Fish safety factor or suitability index computed for each fish species against the three vector mosquitoes showed maximum value for P. reticulata which indicated its higher tolerance than other species. Fishes that exhibited decreased swimming activity on exposure at 1.0 mg/l regained normal activity on withdrawal of exposure. No adverse effect was noticed in the reproduction of...

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

Hexaflumuron's production may result in its release to the environment through various waste streams; it's use as an insecticide(1,2) will result in its direct release to the environment(SRC).

Occupational exposure to hexaflumuron may occur by dermal contact with this compound at workplaces where hexaflumuron is produced or used. (SRC)

Hexaflumuron's production may result in its release to the environment through various waste streams; it's use as an insecticide will result in its direct release to the environment. If released to air, a vapor pressure of 4.43X10-7 mm Hg at 25 °C indicates hexaflumuron will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase hexaflumuron will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18.3 hrs. Particulate-phase hexaflumuron will be removed from the atmosphere by wet and dry deposition. Hexaflumuron absorbs light in the environmental UV spectrum and has the potential for direct photolysis. If released to soil, hexaflumuron is expected to have no mo...

collection=toxvaldb&kind=^LD$

LC50 (rat) > 2,500 mg/m3/4h

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

The substance can be absorbed into the body by ingestion and by inhalation of dust.

collection=toxvaldb&kind=^LC$

LD50 Rat percutaneous >5000 mg/kg

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The effects of five benzoylphenylurea insecticides /including/ ...hexaflumuron... were comparatively evaluated on hematological parameters in rats. Sixty adult Wistar-rats were divided into five dose groups and a control group. Daily doses of 100 mg/kg of each tested insecticide were administered by gavage for 28 days, after which rats were sacrificed and blood was taken for examination. Parameters measured were red blood cell count, hemoglobin (Hb), hematocrit, mean corpuscular volume, mean corpuscular Hb concentration, methemoglobin (metHb), and reticulocyte counts. Results showed that treatment with insecticides at the dose given did not produce any overt signs of toxicity. ...The reticulocyte level was increased in all treated...

First Aid: Inhalation exposure: Fresh air, rest. Skin exposure: Rinse skin with plenty of water or shower. Eyes exposure: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. /from table/