化合物详情

Pesticide Ecotoxicity Data from EPA: 104

LC50 Americamysis bahia (Opossum shrimp, age <24 hr) 0.49 ppm/96 hr (95% confidence limit: 0.32-0.66 ppm); flow through /96.3% AI formulated product/[USEPA, Office of Pesticide Programs; Pesticide Ecotoxicity Database (2000) on alpha-

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tebuconazole, which has a vapor pressure of 1.3x10-8 mm Hg at 20 °C(2) is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase tebuconazole may be removed from the air by wet or dry deposition(SRC). Tebuconazole does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(2).

Using column chromatography, the mean Koc of tebuconazole was calculated to be 1,023(1). In a similar study, a log Koc 2.67 corresponding to a Koc of about 470 was determined using a column loaded with 14 g of soil and assayed via HPLC(2). Using soil thin layer chromatography, a log Koc of 3.7 corresponding to a Koc of 6,000 was determined(3). According to a classification scheme(4), Koc values of 150 to 500 suggest moderate mobility, 500 to 2,000 are low mobility, and values >5,000 are considered to be immobile in soil.

An estimated BCF of 140 was calculated for tebuconazole(SRC), using a log Kow of 3.7(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for tebuconazole is estimated as 1.4X10-10 atm-cu m/mole(SRC) derived from its vapor pressure, 1.3X10-8 mm Hg(1), and water solubility, 36 mg/L (1). This Henry's Law constant indicates that tebuconazole is expected to be essentially nonvolatile from moist soil and water surfaces(2). Tebuconazole is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Tebuconazole is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1) and has been shown to be stable to hydrolysis(2). Tebuconazole does not contain chromophores that absorb at wavelengths >290 nm and has been shown to be stable to photolysis by direct sunlight(2).

Tebuconazole was detected but not quantified in FDA pesticide monitoring studies from 1995, 2000, 2002 and 2003(1-4). These studies analyzed residue in grains, dairy, fish, fruits, vegetables and animal feeds from both the US and foreign sources.

Tebuconazole's production may result in its release to the environment through various waste streams; it's use as a fungicide(1) will result in its direct release to the environment(SRC).

Occupational exposure to tebuconazole may occur through dermal contact with this compound at workplaces where tebuconazole is produced or used. The general population may be exposed to tebuconazole through dermal contact with crops treated with this fungicide or from ingestion of contaminated food. (SRC)

Tebuconazole's production may result in its release to the environment through various waste streams; it's use as a fungicide will result in its direct release to the environment. If released to air, a vapor pressure of 1.28X10-8 mm Hg at 20 °C indicates tebuconazole will exist solely in the particulate phase in the atmosphere. Particulate-phase tebuconazole will be removed from the atmosphere by wet or dry deposition. Tebuconazole does not contain chromophores that absorb at wavelengths >290 nm and has been shown to be stable to photolysis from direct sunlight. If released to soil, tebuconazole is expected to have moderate to no mobility in soil and sediment based on measured Koc data ranging from 470-6,000. Volatilization from moist soil surfaces is not expected to be an important fat...

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LC50 (rat) = 820 mg/m3/4h

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

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Oral Chronic Reference Dose Reference: OPP

LD50 Dog oral 625 mg/kg

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/LABORATORY ANIMALS: Acute Exposure/ Tebuconazole did not irritate the skin of rabbits, and administration of 50 mg into the conjunctival sac did not induce irritation of the eye. In another study, instillation of 100 mg into the conjunctival sac of rabbits caused slight irritation of the conjunctiva.[WHO/FAO; Joint Meeting on Pesticide Residues on Tebuconazole (107534-96-3). Available from, as of July 6, 2006: http://www.inchem.org/pages/jmpr.html]

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...

Reference: Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP