化合物详情

Likelihood score: D (possible rare cause of clinically apparent liver injury).

* Concurrent administration of theophylline and zileuton leads to a reduction in Theophylline clearance within 5 days. Clinicians should monitor the plasma concentrations of theophylline in patients and reduce the dosage accordingly. Adjust the maintenance dose if the patient is already on zileuton.

Overdose is treated based on symptoms with supportive care if a patient has signs of toxicity. Dialysis does not remove zileuton from the bloodstream. Treatment with gastric lavage may be necessary to eliminate any unabsorbed drug. Limited guidelines exist around the approach to overdose. According to product labeling, a case report of a patient taking between 6.6 and 9.0 g of zileuton and completely recovering without complications is reported. The clinician should consult a medical toxicologist or poison control center for up-to-date information on the management of zileuton overdose. The American Association of Poison Control Centers and National Poison Data System research reinforces the importance of expertise and the need for specialized medical toxicology knowledge to manage drug...

References: DOI:10.1016/j.drudis.2019.09.022

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