化合物详情

Vitreous samples from 9 eyes of 9 patients and plasma samples from 4 patients were assayed with high-performance liquid chromatography to determine cidofovir levels. The only eye that had a detectable vitreous concentration (673.7 ng/ml) was injected with 20 ug 24 hours prior to the surgery. The remaining samples including plasma were below the detection point of the assay (100 ng/ml) and were injected between 5 and 40 days prior to sampling.

Placement of a ganciclovir ocular implant in patients receiving IV cidofovir has resulted in profound hypotony in some patients, and some clinicians suggest that IV cidofovir not be administered within one month before or after placement of a ganciclovir ocular implant.

Likelihood score: E (unlikely cause of clinically apparent liver injury).

/CASE REPORTS/ A diagnosis of Fanconi's syndrome, as manifested by multiple abnormalities of proximal renal tubular function, was reported in 1% of patients. Decreases in serum bicarbonate to < or =16 mEq/L occurred in 16% of cidofovir-treated patients. Cases of metabolic acidosis in association with liver dysfunction and pancreatitis resulting in death have been reported in patients receiving /cidofovir/.

References: DOI:10.1016/j.drudis.2019.09.022

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Studies showed that cidofovir caused inhibition of spermatogenesis in rats and monkeys. However, no adverse effects on fertility or reproduction were seen following once weekly iv injections of cidofovir in male rats for 13 consecutive weeks at doses up to 15 mg/kg/wk... . Female rats dosed iv once weekly at 1.2 mg/kg/wk...or higher, for up to 6 weeks prior to mating and for 2 weeks post mating had decreased litter sizes and live births/litter and increased early resorptions/litter. Peri- and post-natal development studies in which female rats received sc injections of cidofovir once daily at doses up to 1.0 mg/kg/day from day 7 of gestation through day 21 postpartum (approx 5 weeks) resulted in no adverse effects on viability...

Two cases of cidofovir overdose have been reported. These patients received single doses of /cidofovir/ at 16.3 mg/kg and 17.4 mg/kg respectively, with concomitant oral probenecid and intravenous hydration. In both cases, the patients were hospitalized and received oral probenecid and vigorous iv hydration with normal saline for 3 to 5 days. Significant changes in renal function were not observed in either patient.

◉ Effects on Lactation and Breastmilk