化合物详情

Pesticide Ecotoxicity Data from EPA: 75

LC50 Anas platyrhynchos (Mallard duck) dietary >5620 mg/kg (5 days)

Stability in water DT50 484.8 days (pH 5), 17.7 days (pH 7), 0.2 days (pH 9). In light DT50 of 4.92 days.

The Koc of fluthiacet-methyl is estimated as 2,700(SRC), using a log Kow of 3.77(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that fluthiacet-methyl is expected to have slight mobility in soil.

An estimated BCF of 160 was calculated for fluthiacet-methyl(SRC), using a log Kow of 3.77(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not altered physically or chemically once released into the environment.

The Henry's Law constant for fluthiacet-methyl is estimated as 2.1X10-9 atm-cu m/mole(SRC) derived from its vapor pressure, 3.31X10-9 mm Hg(1), and water solubility, 0.85 mg/L(1). This Henry's Law constant indicates that fluthiacet-methyl is expected to be essentially nonvolatile from water surfaces(2). Fluthiacet-methyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

A hydrolysis half-life of 18 days at pH 7 and a photolysis on soil half-life of 21 days have been reported for fluthiacet-methyl(2).

Fluthiacet-methyl's production may result in its release to the environment through various waste streams; it's use as a herbicide(1) will result in its direct release to the environment(SRC).

Occupational exposure to fluthiacet-methyl may occur through inhalation and dermal contact with this compound at workplaces where fluthiacet-methyl is produced or used. (SRC)

Fluthiacet-methyl's production may result in its release to the environment through various waste streams; it's use as a herbicide will result in its direct release to the environment. If released to air, a vapor pressure of 3.31X10-9 mm Hg at 25 °C indicates fluthiacet-methyl will exist solely in the particulate phase in the ambient atmosphere. Particulate-phase fluthiacet-methyl will be removed from the atmosphere by wet and dry deposition. A half-life in light of 4.92 days has been reported. If released to soil, fluthiacet-methyl is expected to have slight mobility based upon an estimated Koc of 2,700. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.1X10-9 atm-cu m/mole. A photolysis half-life o...

collection=toxvaldb&kind=^EL$

LC50 (rat) >5,000 mg/m3

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Oral Slope Factor Reference: OPP

No indication of carcinogenicity to humans (not listed by IARC).

LD50 Rabbit dermal >2000 mg/kg

collection=toxvaldb&kind=^RRV$

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ In the mouse carcinogenicity study the systemic toxicity NOAEL was 0.1 mg/kg/day in males and females and the systemic toxicity LOAEL was 1.0 mg/kg/day in males and 1.2 mg/kg/day in females based on non-neoplastic liver findings. In males at 10 and 32 mg/kg/day, respectively, there was an increase in the number of mice with hepatocellular adenomas, carcinomas and/or adenomas/carcinomas.

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/