化合物详情

CAS122111-03-9

分子式C9H11F2N3O4·HCl

分子量299.66 g/mol g/mol

危化品

Gemcitabine Hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2016.02.015