一键配货
化合物详情
CAS123441-03-2
分子式C14H22N2O2
分子量250.34 g/mol g/mol
非危品
Rivastigmine is a carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a cholinergic drug and a neuroprotective agent. It is a carbamate ester and a tertiary amino compound. It is a conjugate base of a rivastigmine(1+).
科学粮草官-词典编辑部，修订于：2026-07-06
Toxicity
ToxicityEffect Level
collection=toxvaldb&kind=^EL$
Hepatotoxicity
Likelihood score: D (possible, rare cause of clinically apparent drug-induced liver injury).
Adverse Effects
Long-term use of rivastigmine has also been associated with an increased risk of death compared to patients treated with donepezil.
Toxicity Summary
In addition to serious manifestations of common side effects, clinical staff members should always look for cholinergic crises whenever prescribing anticholinergic medications. Classic manifestations of a patient in crisis can be remembered by the mnemonic DUMBELS - diarrhea, urination, miosis, bradycardia, excitability, lacrimation, salivation/excessive sweating before treatment. Patients experiencing a cholinergic crisis should have atropine followed by pralidoxime to reverse the anticholinergic effects of rivastigmine. While the usual treatment of the crisis involves giving atropine before pralidoxime, a case study done in 2009 showed a successful reversal of cholinergic crisis with just pralidoxime without atropine pretreatment.
Drug Induced Liver Injury
References: DOI:10.1016/j.drudis.2019.09.022
