一键配货
化合物详情
CAS159989-64-7
分子式C32H45N3O4S
分子量567.78 g/mol g/mol
非危品
Nelfinavir is an aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties. It has a role as an antineoplastic agent and a HIV protease inhibitor. It is a member of benzamides, an organic heterobicyclic compound, a member of phenols, a secondary alcohol, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a nelfinavir(1+).
科学粮草官-词典编辑部，修订于：2026-07-06
Toxicity
ToxicityHepatotoxicity
Likelihood score: D (possible rare cause of clinically apparent liver injury).
Drug Induced Liver Injury
References: DOI:10.1016/j.drudis.2019.09.022
Effects During Pregnancy and Lactation
Gynecomastia has been reported among men receiving highly active antiretroviral therapy. Gynecomastia is unilateral initially, but progresses to bilateral in about half of cases. No alterations in serum prolactin were noted and spontaneous resolution usually occurred within one year, even with continuation of the regimen. Some case reports and in vitro studies have suggested that protease inhibitors might cause hyperprolactinemia and galactorrhea in some male patients, although this has been disputed. The relevance of these findings to nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
