化合物详情

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2-(Methylpropyl)quinoline as described in this fragrance ingredient safety assessment. It was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are less than 1.

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2-(Methylpropyl)quinoline as described in this fragrance ingredient safety assessment. Data from read-across analog 2-isobutylquinoline (CAS # 93-19-6) show that 2-(methylpropyl)quinoline is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-(methylpropyl)quinoline is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog quinoline (CAS # 91-22-5) show that there are no safety concerns for 2-(methylpropyl)quinoline for skin sensitization under the...