化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Isosulfan Blue, which has an estimated vapor pressure of 1.9X10-36 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase Isosulfan Blue may be removed from the air by wet or dry deposition(SRC). Structurally similar Sulfan Blue absorbs light at 635 nm(3); therefore, by analogy, Isosulfan Blue may be susceptible to direct photolysis by sunlight(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of Isosulfan Blue can be estimated to be 5.5X10+6(SRC). According to a classification scheme(2), this estimated Koc value suggests that Isosulfan Blue is expected to be immobile in soil. Analogous Sulfan Blue is an anionic dye(3). Therefore, by analogy, Isosulfan Blue may exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

An estimated BCF of 3 was calculated in fish for Isosulfan Blue(SRC), using an estimated log Kow of -2.34(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Structurally similar Sulfan Blue is an anionic dye(1). Therefore, by analogy, Isosulfan Blue will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. Isosulfan Blue is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.9X10-36 mm Hg(SRC), determined from a fragment constant method(3).

Isosulfan Blue may undergo hydrolysis in the environment due to the presence of functional groups that hydrolyze under environmental conditions(1). Analogous Sulfan Blue absorbs light at 635 nm(2); therefore, Isosulfan Blue may be susceptible to direct photolysis by sunlight(SRC).

While data specific to Isosulfan Blue were not located(SRC, 2012), the literature suggests that some pharmaceutically active compounds originating from human and veterinary therapy are not eliminated completely in municipal sewage treatment plants and are therefore discharged into receiving waters(1). Wastewater treatment processes often were not designed to remove them from the effluent(2). Selected organic waste compounds may be degrading to new and more persistent compounds that may be released instead of or in addition to the parent compound(2).

Isosulfan Blue's production and use as a diagnostic contrast agent(1) may result in its release to the environment through various waste streams(SRC).

Occupational exposure to Isosulfan Blue may occur through inhalation and dermal contact with this compound at workplaces where Isosulfan Blue is produced or used. Exposure to Isosulfan Blue among the general population may be limited to those administered the drug, a diagnostic contrast agent. (SRC)

Isosulfan Blue's production and use as a diagnostic contrast agent may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 1.9X10-36 mm Hg at 25 °C indicates Isosulfan Blue will exist solely in the particulate phase in the atmosphere. Particulate-phase Isosulfan Blue will be removed from the atmosphere by wet or dry deposition. Sulfan Blue, which is strucrually similar to Isosulfan Blue, absorbs light at 635 nm. Therefore, by analogy, Isosulfan Blue may be susceptible to direct photolysis by sunlight. If released to soil, Isosulfan Blue is expected to be immobile based upon an estimated Koc of 5.5X10+6. However, by analogy to Sulfan Blue which is an anionic dye, Isosulfan Blue may exist almost entirely in the anion f...

/CASE REPORTS/ Hypersensitivity Reactions: Case series report an overall incidence of hypersensitivity reactions in approximately 2% of patients. Life-threatening anaphylactic reactions have occurred. Manifestations include respiratory distress, shock, angioedema, urticaria, pruritus. A death has been reported following administration of a similar compound employed to estimate the depth of a severe burn. Reactions are more likely to occur in patients with a personal or family history of bronchial asthma, significant allergies, drug reactions or previous reactions to triphenylmethane dyes.

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...