化合物详情

/SRP 1988: THIS PCB, BEING FOUND IN CLOPHEN A30, A40, A50, AND A60 BUT NOT IN AROCLORS/ ... FROM MANUFACTURING PLANTS, DURING DESTRUCTION OF MANUFACTURED ARTICLES CONTAINING PCBS IN MUNICIPAL & INDUSTRIAL WASTE-DISPOSAL BURNERS, THROUGH GRADUAL WEAR & WEATHERING OF PCB-CONTAINING PRODUCTS, & THROUGH LEACHING FROM LAND-FILL DUMPS.

Chronic PCB exposure results in symptoms such as abdominal pain, nausea, vomiting, diarrhea, headache, dizziness, depression, nervousness, dermal and ocular lesions, fatigue, irregular menstrual cycles and a lowered immune response. (A3)

There are no specific treatments for PCB poisoning, since it is not usually recognized until after substantial chronic exposure. Only preventing further exposure and treating the observed symptoms can be done. Acute inhalation can be treated by administering oxygen. (L4)

LD50: 1010 mg/kg (Oral, Rat) (T14) LD50: 880 mg/kg (Intraperitoneal, Mouse) (T14)

The most common health effects of PCBs are skin conditions such as chloracne and rashes. Chronic PCB exposure has also been shown to cause liver, stomach and kidney, damage, jaundice, edema, anemia, changes in the immune system, behavioral alterations, and impaired reproduction. (L4)

IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.

Oral (L4); inhalation (L4); dermal (L4)

The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uterog...

Intermediate Oral: 0.03 ug/kg/day (L134)

Oral Slope Factor Reference: WHO/TEF

Food and Environmental Agents: Reported Sign or Symptom in Infant or Effect on Lactation: Polychlorinated biphenyls and polybrominated biphenyls: Lack of endurance, hypotonia, sullen, expressionless facies. /From Table 7/

1, carcinogenic to humans. (L135)

ISOMERICALLY PURE PCBS WERE TESTED AS INDUCERS OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT. THE CHLORINATED BIPHENYL ISOMERS CAN BE CATEGORIZED INTO 2 DISTINCT GROUPS OF INDUCERS, WHILE COMMERCIAL PCB MIXT HAVE CHARACTERISTICS OF BOTH GROUPS. BIPHENYLS CHLORINATED SYMMETRICALLY IN BOTH THE META AND PARA POSITIONS INCREASE THE FORMATION OF CYTOCHROME P448, BUT DECREASE THE AMINOPYRINE N-DEMETHYLASE ACTIVITY. BIPHENYL ISOMERS CHLORINATED IN BOTH THE PARA AND ORTHO POSITIONS INDUCE THE FORMATION OF CYTOCHROME P450 AND N-DEMETHYLASE ACTIVITY. ISOMERS WHICH ARE CHLORINATED IN ONLY 1 RING, OR ARE CHLORINATED IN BOTH RINGS BUT NOT IN THE PARA POSITIONS, HAVE VERY LITTLE ACTIVITY AS INDUCERS OF LIVER ENZYMES.

Fraction of Contaminant Absorbed Dermally from Soil: 0.14000000000000001

Fraction of Contaminant Absorbed Dermally from Soil: 0.14000000000000001