2-bromodibenzofuran

接触眼睛可导致发红和疼痛。

2-溴二苯并呋喃是一种催泪剂。

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

作为一种强催泪剂，最可能的蛋白质靶标之一是在眼睛、鼻子、嘴巴和肺的感觉神经(三叉神经)中表达的TRPA1离子通道。卤代二苯并呋喃(PCDFs和PBDFs)与芳烃受体(AhR)结合，增强其在XRE(外源性反应元件)启动子区域激活转录的能力。具体来说，AhR与PCDF结合，将其转移到细胞核，并与烃核转位蛋白(ARNT)和外源性反应元件(XRE)一起增加CYP1A1和芳烃羟化酶(CYP1B1)的表达。AhR信号传导还通过环氧化酶-2增加花生四烯酸转化为前列腺素的转化，改变Wnt/β-连环蛋白信号传导下调Sox9并改变信号传导...

无致癌性迹象(未被IARC列出)。(L135)

吸入 (L952)；皮肤 (L952)；口服 (L952)