化合物详情

LC50; Species: Oryzias latipes (Medaka); Conditions: static freshwater; Concentration: > 500 mg/L for 48 hr; Dissolved Oxygen: 7.3-4.3 mg/L Test Temperature and Units: Value/Lower Range: 23 Upper Range: 27

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexahydrophthalic anhydride, which has an estimated vapor pressure of 5.3X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexahydrophthalic anhydride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hrs(SRC), calculated from its rate constant of 6.8X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Hexahydrophthalic anhydride does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is no...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of hexahydrophthalic anhydride can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that hexahydrophthalic anhydride is expected to have very high mobility in soil.

AEROBIC: Hexahydrophthalic anhydride reached 4% of its theoretical BOD in 28 days in the Japanese MITI test(1).

An estimated BCF of 13 was calculated in fish for hexahydrophthalic anhydride(SRC), using an estimated log Kow of 2.17(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for hexahydrophthalic anhydride is estimated as 2.1X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that hexahydrophthalic anhydride is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.3 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 20 days(SRC). Hexahydrophthalic anhydride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Hexahydrophthalic anhydride is not expected to volatilize from dry soil surfaces(SRC) based upon...

The rate constant for the vapor-phase reaction of hexahydrophthalic anhydride with photochemically-produced hydroxyl radicals has been estimated as 6.8X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 19 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Hexahydrophthalic anhydride is expected to undergo hydrolysis in the environment due to the presence of functional groups that hydrolyze under environmental conditions(2). Hexahydrophthalic anhydride does not contain chromophores that absorb at wavelengths >290 nm(2), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The substance is harmful to aquatic organisms.

Hexahydrophthalic anhydride's production and use as a chemical intermediate and hardener in epoxy resins(1) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 15,061 workers (7,356 of these were female) were potentially exposed to hexahydrophthalic anhydride in the US(1). Occupational exposure to hexahydrophthalic anhydride may occur through inhalation and dermal contact with this compound at workplaces where hexahydrophthalic anhydride is produced or used(SRC). Hexahydrophthalic anhydride levels were measured in urine samples from 20 workers exposed to air levels of 11-220 ug hexahydrophthalic anhydride/cu m in plants manufacturing electrical capacitors and automotive ignition systems. Approximately 900 nmol/mmol creatine was reported after 6 hrs of exposure with levels dropping to 50 nmol/mmol by 18 hours post exposure(2).

Hexahydrophthalic anhydride's production and use as a chemical intermediate and hardener in epoxy resins may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 5.3X10-2 mm Hg at 25 °C indicates hexahydrophthalic anhydride will exist solely as a vapor in the atmosphere. Vapor-phase hexahydrophthalic anhydride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 19 hours. Hexahydrophthalic anhydride does not contain chromophores that absorb at wavelengths >290 nm, and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, hexahydrophthalic anhydride is expected to have very h...

Ingestion Exposure: Sore throat. Burning sensation. Abdominal pain. Diarrhoea.

collection=toxvaldb&kind=^LD$

LC50 (rat) > 1,100 mg/m3/4hr

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

The substance can be absorbed into the body by inhalation.

collection=toxvaldb&kind=^LC$

/HUMAN EXPOSURE STUDIES/ 53 humans. 5% suspension of hexahydro-1,3-isobenzofurandione in mineral oil (10 repeat test). Four out of fifty-three subjects gave a low grade sensitivity reaction and one marked reaction indicating sensitization. Interpretation of Results: Sensitizing .

LD50 Rats oral 2700 to 2800 mg/kg

/GENOTOXICITY/ Ames Salmonella typhimurium assay in strains TA98, TA100, TA1535, TA1537, and TA1538 with and without metabolic activation at concentrations up to 1000 ug/plate (maximum concentration): Negative.

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...