化合物详情

Pesticide Ecotoxicity Data from EPA: 84

LD50; Species: /Apis mellifera/ (Honey bee) contact >25 ug ai/bee

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cloransulam-methyl, which has a vapor pressure of 3.0X10-16 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase cloransulam-methyl may be removed from the air by wet or dry deposition(SRC).

Assessment in the field indicates little movement of cloransulam-methyl into the soil profile; residues are contained in the upper 12 to 18 inches of soil(1). Observed cloransulam-methyl Koc values ranged from 54.4 to 915 after three months incubation on six different soil types(1); greater adsorption at low versus high soil pH(1); sorption tends to increase with time associated with the soil(1). In a 55-day incubation study using 16 different soil types(2), time-averaged Koc values ranged from 12 to 262; apparent sorption (as measured by Kd) was observed to generally increase by as much as 10-fold over time(2). According to a classification scheme(3), these Koc values suggest that cloransulam-methyl is expected to have very high to low mobility in soil. Field studies conducted in Wisco...

ANAEROBIC: An anaerobic aquatic biodegradation rate of 0.043/day with a half-life of 16 days was reported for cloransulam-methyl(1).

An estimated BCF of 3 was calculated in fish for cloransulam-methyl(SRC), using a log Kow of -0.365(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

A pKa of 4.81(1) indicates cloransulam-methyl will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water and moist soil surfaces is not expected to be an important fate process. Cloransulam-methyl is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor of 3.0X10-16 mm Hg(1).

The aqueous hydrolysis half-life of cloransulam-methyl is reported as >365, 118 to 231 and 3 days at pH 5, 7 and 9, respectively(1). A hydrolysis half-life of 10 days in natural water at an approximate pH of 8 and 67 days in a soil slurry at an approximate pH 6.5 were also reported(1). Photolysis half-lives of cloransulam-methyl were reported as 54 minutes and 13 days for aqueous and moist soil, respectively(1).

/AQUATIC SPECIES/ No mortality or sublethal effects from cloransulam-methyl exposure were reported for the grass shrimp; the 96-hr LC50 was >121 mg a.i./L. In contrast, effects on mean shell deposition to the Eastern oyster were reported at the limit concentration (111 mg a.i./L) tested. Mean shell deposition was decreased 18% compared to the negative control, and no additional adverse effects were noted. The 96-hr EC50 for Eastern oyster was >111 mg a.i./L (most sensitive estuarine/marine invertebrate acute toxicity endpoint) and the 96-hr NOAEC was < 111 mg a.i./L based on mean shell deposition.

Cloransulam-methyl's production may result in its release to the environment through various waste streams; its use as a herbicide(1) will result in its direct release to the environment(SRC).

Occupational exposure to cloransulam-methyl may occur through inhalation and dermal contact with this compound at workplaces where cloransulam-methyl is produced or used. (SRC)

Cloransulam-methyl's production may result in its release to the environment through various waste streams; its use as a herbicide will result in its direct release to the environment. If released to air, a vapor pressure of 3.0X10-16 mm Hg at 25 °C indicates cloransulam-methyl will exist solely in the particulate phase in the atmosphere. Particulate-phase cloransulam-methyl will be removed from the atmosphere by wet or dry deposition. If released to soil, cloransulam-methyl is expected to have very high to low mobility based upon Koc values of 12 to 915. The pKa of cloransulam-methyl is 4.81, indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than thei...

collection=toxvaldb&kind=^EL$

LC50 (rat) >3,770 mg/m3

Oral Chronic Reference Dose Reference: OPP

LD50 Rabbit dermal >2000 mg/kg

collection=toxvaldb&kind=^RRV$

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Dosages of 100, 500, or 1000 mg/kg/day fed to B6C3F1 mice for 2 weeks produced slight hepatocellular hypertrophy at 500 mg/kg/day and above in males, and at 1000 mg/kg/day in females. The NOEL was 100 mg/kg/day. Dosages ranging from 50 to 1000 mg/kg/day given for 13 weeks produced slight centrilobular and midzonal hepatocellular hypertrophy at 100 mg/kg/day and above in males, and at 500 mg/kg/day and above in females. Electron microscopy characterized the hypertrophy as an increase in rough endoplasmic reticulum (RER) with a decrease in cytoplasmic glycogen content. Kidney effects in mice consisted of decreased vacuolation of the renal tubules, consistent with decreased cytoplasmic lipid, accompanied by lower kidney weights at 500...

Cancer Classification: Group E Evidence of Non-carcinogenicity for humans

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...