Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is sμggested that piperine exerts its chemopreventive effect by aμgmenting antioxidant defense system and modulating lipid peroxidation.A black pepper extract TRPV1 activator. Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. A black pepper extract TRPV1 activator.