Aliskiren Hydrochloride 是一种直接的肾素抑制剂，IC | 50 | = 0.72 nM。肾素是肾素-血管紧张素-醛固酮系统（RAAS）中的第一种酶，可将一种非活性肽血管紧张素原裂解为血管紧张素I。抑制肾素可防止这种裂解和随后的血管紧张素II受体活化。 Aliskiren hydrochloride is a direct renin inhibitor with an IC|50|= 0.72 nM. Renin is the first enzyme in the renin-angiotensin-aldosterone system (RAAS) and cleaves angiotensinogen, an inactive peptide, into angiotensin I. Inhibition of renin prevents this cleavage and subsequent activiation of angiotensin II receptors.