Amitifadine hydrochloride

小分子

盐酸阿米替拉定

Amitifadine hydrochloride

A646841-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) , with IC 50 s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively. In Vitro Amitifadine (DOV 21,947) is an antidepressant drug. K i values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC 50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self-administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session, but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smoking cessation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 12 nM (serotonin), 23 nM (norepinephrine), 96 nM (dopamine)

盐酸阿米替法汀是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂（SNDRI），在 HEK 293 细胞中对血清素、去甲肾上腺素和多巴胺的 IC 50 s 分别为 12、23 和 96 nM。

410074-74-7

C11H12Cl3N

264.58 g/mol

11680542

C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl

C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl

11680542

DMSO : ≥ 100 mg/mL (377.96 mM) H2O : 50 mg/mL (188.98 mM; Need ultrasonic)

2

1

1

263.004 Da

263.004 Da

12.000 Ų

15

0

245.000

0

2