AZD1979 is a Melanin-concentrating hormone receptor 1 ( MCHr1 ) antagonist with an IC 50 of ~12 nM. In Vivo In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: ~12 nM (MCHr1)