Antihistamine-1 is a H1-antihistamine ( K i =6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC 50 s of 5.4 and 0.8 μM, respectively. In Vitro Antihistamine-1 (Compound 2) is a H1-antihistamine (K i =6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC 50 s of 5.4 and 0.8 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP2D6 5.4 μM (IC 50 )