ALS-8112

小分子

4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | Cytidine, 2'-deoxy-2'-fluoro-4'-c-alpha-chloromethyl- | HY-12983 | 1445379-92-9 | ALS-8176 (active form) | CYTIDINE, 2'-DEOXY-2'-FLUOR

ALS-8112

A648901-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM. In Vitro The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.02 μM ( RSV )

ALS-8112 是一种强效的选择性呼吸道合胞病毒（RSV）聚合酶抑制剂。ALS-8112 的 5'-triphosphate 形式可抑制 RSV 聚合酶，其 IC 50 为 0.02 μM。

1445379-92-9

C10H13ClFN3O4

293.68 g/mol

71621663

C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)CCl)O)F

4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1

AWSRKKBIPSQHOJ-IBCQBUCCSA-N

C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)CCl)O)F

71621663

1445379-92-9

DMSO : ≥ 47 mg/mL (160.04 mM)

3

5

3

293.058 Da

293.058 Da

108.000 Ų

19

0

446.000

0

1

-1.200