AZD-9574

小分子

AZD-9574

A649158-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD + breast cancer and advanced solid malignancies research In Vitro AZD-9574 inhibits PARP1 enzymatic activity with IC 50 s range between 0.3-2 nM in all tested cell lines irrespective of the homologous recombination repair (HRR) status. In isogenic cell lines pairs confirms higher potency and selectivity towards HRR-deficient (HRD + ) models (DLD1 BRCA2 -/- ; SKOV-3 BRCA2 -/- and SKOV-3 PALB2 -/- ). The IC 50 in BRCA2 -/- DLD1 cells is 1.38 nM compared to IC 50 >40 µM BRCA2 wt cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AZD-9574 (3 mg/kg) shows sustained tumour growth suppression resulting in a significantly extended survival of tumour-bearing mice, in intracranial xenograft model of breast cancer brain metastases . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PPAR

AZD-9574 是一种强效的脑穿透性 PARP1 抑制剂，与 PARP2/3/5a/6 相比，它对 PARP1 的选择性大于 8000 倍。AZD-9574 通过选择性抑制和捕获 SSB 位点上的 PARP1 来发挥作用。AZD-9574 是一种抗癌剂，可用于

2756333-39-6

C21H22F2N6O2

428.44 g/mol

162524593

CC1=NC2=C(C(=C(C=C2)CN3CCN(CC3)C4=C(N=C(C=C4)C(=O)NC)F)F)NC1=O

CC1=NC2=C(C(=C(C=C2)CN3CCN(CC3)C4=C(N=C(C=C4)C(=O)NC)F)F)NC1=O

162524593

DMSO : 22.22 mg/mL (51.86 mM; ultrasonic and adjust pH to 4 with HCl) DMSO : 8.33 mg/mL (19.44 mM; ultrasonic and warming and heat to 60°C)

2

8

4

428.177 Da

428.177 Da

89.900 Ų

31

0

714.000

0

1

1.200