AP39

小分子

AP39

A651461-5mg

5mg

≥95%

2-8°C储存,干燥

冰袋运输

AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H 2 S) donor. AP39 increases intracellular H 2 S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research . In Vitro AP39 (25,100 nM; for 24 h) results in increase in cell viability in APP/PS1 neurons and has no effect on cell viability in WT neurons. AP39 (100 nM) increases the levels of OPA1 and Mfn1 but not Mfn2. Moreover, AP39 decreases the levels of Fis1 but not Drp1. AP39 (25-250 nM; 2 h) induces a concentration-dependent increase in H 2 S generation and in the fluorescence of the H 2 S-detecting dye AzMC. AP39 (100 nM) significantly increases the basal respiratory rate and the OCR-linked maximal respiratory capacity of the APP/PS1 neurons. AP39 significantly increases the ATP production in WT and APP/PS1 neurons. AP39 significantly protects against mtDNA damage in APP/PS1 neurons by partially restoring mtDNA integrity. AP39 consists of a mitochondria-targeting motif, triphenylphosphonium (TPP + ), coupled to a H 2 S-donating moiety (dithiolethione) by an aliphatic linker.\nAP39 (100 nM) reduces intracellular oxidative stress and in the meantime it consequently sustaines the cell viability, mitochondrial respiration and mitochondrial DNA integrity. These effects tend to be stimulatory at lower concentrations (30 and 100 nM), but tend to diminish or convert into inhibitory effects at a higher concentration (300 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AP39 (100 nM/kg/day; ip; for 6 weeks) ameliorates the learning and memory deficits of APP/PS1 mice. AP39 (25-250 nM/kg/day; ip; for 6 weeks) induces a dose-dependent increase in H 2 S generation in the cortex and hippocampus of WT and APP/PS1 mice . AP39 (0.01, 0.1, 1 μmol/kg; iv; bolus 10 min before reperfusion) dose‐dependently reduces infarct size anaesthetized by thiobutabarbital (200 mg/kg, i.p) in male Sprague Dawley rats, 300-350 g (9-11 weeks). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-month-old WT or APP/PS1 mice Dosage: 100 nM/kg Administration: IP; daily; for 6 weeks Result: Reversed the spatial learning and memory deficits of the aged AD model mice. Alleviated brain atrophy and ventricle asymmetryand inhibited Aβ plaque deposition in the brains in AD model mice. Form:Solid

AP39 是一种三苯基膦衍生化的茴香硫醚二硫代二酮和线粒体靶向硫化氢（H 2 S）供体。AP39 可提高细胞内 H 2 S 的水平。AP39 具有细胞保护作用，并能在氧条件下保持线粒体 DNA 的完整性。

1429061-80-2

C37H38BrO2PS3

721.77 g/mol

71537388

C1=CC=C(C=C1)[P+](CCCCCCCCCC(=O)OC2=CC=C(C=C2)C3=CC(=S)SS3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

[10-oxo-10-[4-(5-sulfanylidenedithiol-3-yl)phenoxy]decyl]-triphenylphosphanium;bromide

1S/C37H38O2PS3.BrH/c38-36(39-31-26-24-30(25-27-31)35-29-37(41)43-42-35)23-15-4-2-1-3-5-16-28-40(32-17-9-6-10-18-32,33-19-11-7-12-20-33)34-21-13-8-14-22-34;/h6-14,17-22,24-27,29H,1-5,15-16,23,28H2;1H/q+1;/p-1

PUEBFERUDPTIDR-UHFFFAOYSA-M

C1=CC=C(C=C1)[P+](CCCCCCCCCC(=O)OC2=CC=C(C=C2)C3=CC(=S)SS3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

71537388

DMSO : 100 mg/mL (138.55 mM; Need ultrasonic)