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名称
ARN-21934
分子类型
未知
英文名称
ARN-21934
货号
A651864-5mg
包装规格
5mg
浓度
≥98%
储存温度
-20°C储存
运输条件
超低温冰袋运输
产品介绍
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC 50 of 2 μM as compared to the anticancer agent Etoposide (IC 50 =120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research In Vitro ARN-21934 display a different affinity for topoIIα and topoIIβ. ARN-21934 is more potent against the α isoform, the IC 50 value for the inhibition of DNA relaxation by topoIIα is 2 μM, the value for inhibition of DNA relaxation by topoIIβ is 120 μM. ARN-21934 exhibits a small panel of human cancer cell lines. It against melanoma (A375 and G-361), breast (MCF7), endometrial (HeLa), lung (A549), and androgen-independent prostate (DU145) cancer cells with IC 50 values of 12.6 μM, 8.1 μM, 15.8 μM, 38.2 μM, 17.1 μM, and 11.5 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ARN-21934 (intraperitoneal injection; 10 mg/kg; single dose) reaches a maximal plasma concentration of 0.68 μg/mL after 15 min. The half-life is 149 min in circulation, still being present in plasma 360 min after injection. The compound also exhibits good clearance values (0.116 L/(min kg)). Besides, ARN-21934 is able to reach the brain, with a maximum concentration of compound at 60 min, and is still present in the brain 360 min after injection MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:topoisomerase II alpha topoisomerase II beta
生化机理
ARN-21934 是一种强效、高选择性、血脑屏障 (BBB) 穿透性抑制剂，可抑制人类拓扑异构酶 II α 和 β。ARN-21934还能
CAS号
2230854-93-8
分子式
C21H24N6
分子量
360.46 g/mol
PubChem编号
135150944
Isomeric SMILES
CN(C)C1=CC=C(C=C1)NC2=NC(=NC3=C2CC(CC3)N)C4=CC=NC=C4
IIUPAC Name
4-N-[4-(dimethylamino)phenyl]-2-pyridin-4-yl-5,6,7,8-tetrahydroquinazoline-4,6-diamine
INCHI
1S/C21H24N6/c1-27(2)17-6-4-16(5-7-17)24-21-18-13-15(22)3-8-19(18)25-20(26-21)14-9-11-23-12-10-14/h4-7,9-12,15H,3,8,13,22H2,1-2H3,(H,24,25,26)
InChi Key
CKXSRLUXTFDZCF-UHFFFAOYSA-N
Smiles
CN(C)C1=CC=C(C=C1)NC2=NC(=NC3=C2CC(CC3)N)C4=CC=NC=C4
PubChem CID
135150944
溶解性
DMSO : 8.33 mg/mL (23.11 mM; ultrasonic and warming and heat to 80°C)
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
6
可旋转键计数Rotatable Bond Count
4
精确质量Exact Mass
360.206 Da
单同位素质量Monoisotopic Mass
360.206 Da
拓扑极表面积Topological Polar Surface Area
80.000 Ų
重原子数Heavy Atom Count
27
形式电荷Formal Charge
0
复杂度Complexity
458
同位素原子数Isotope Atom Count
0
共价键合单元计数Covalently-Bonded Unit Count
1
XLogP3
2.6
危险属性
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上下游信息
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技术文档
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相关文章
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ARN-21934 5mg
品牌：阿拉丁
货号：A651864-5mg
级别： ≥98%
货期：30天
已售 155 件
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