AZD9056 hydrochloride

小分子

AZD9056 盐酸盐

AZD9056 hydrochloride

A654744-1ml

1ml

Moligand™

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

AZD9056 hydrochloride 是具有口服活性的P2X7选择性抑制剂，其在炎症和引起疼痛的疾病中起重要作用。 AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. In Vitro The antagonist AZD9056 blocks P2X7 receptors with an IC 50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor. The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC 50 =1-3 μM) in mouse microglia BV2 cells. AZD9056 is an inhibitor of BCRP and weakly inhibits BCRP-mediated transport of methotrexate (IC 50 =92 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Treatment with AZD9056 exerts pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:P2X7 Receptor

AZD9056 盐酸盐是一种选择性口服活性 P2X7 抑制剂，P2X7 在炎症和致痛疾病中发挥着重要作用。

345303-91-5(DMSO)

C24H36Cl2N2O2

455.46 g/mol

C1C2CC3CC1CC(C2)(C3)CNC(=O)C4=C(C=CC(=C4)CCCNCCCO)Cl.Cl