AGI-24512

AGI-24512

A656261-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

AGI-24512 is a potent methionine adenosyltransferase 2α ( MAT2A ) inhibitor, with an IC 50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro . AGI-24512 can be used for researching anticancer In Vitro AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC 50 of 100 nM. AGI-24512 significantly increases in γH2AX-positive cells in MTAP -/- HCT116 cells. AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC 50 of 95 nM in MTAP -/- cells. AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP- cell, with an IC 50 of 100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AGI-24512 shows poor oral absorption and a short half-life in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 8 nM (MAT2A)

AGI-24512 是一种强效的蛋氨酸腺苷转移酶 2α （MAT2A）抑制剂，IC50 为 8 nM。AGI-24512 触发 DNA 损伤反应。AGI-24512 可在体外阻断缺失 MTAP 的癌细胞的增殖。AGI-24512 可用于研究抗肿瘤药物。

2201066-53-5(DMSO)

C24H24N4O2

400.47 g/mol

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