Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC 50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR , and Anagyrine can directly, without metabolism, desensitize nAChR . In Vitro Anagyrine acts as a partial agonist in both cell lines with EC 50 values of 4.2 and 231 μM in SH-SY5Y and TE-671 cells, respectively. Anagyrine is a desensitizer of nAChR with DC 50 values of 6.9 and 139 μM in SH-SY5Y and TE-671 cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil