Information Alflutinib (AST2818) mesylate is a third-generationepidermal growth factor receptor (EGFR)inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potentCYP3A4inducer with EC50 of 0.25 μM. Targets EGFR ; CYP3A4 (Cell-free assay) ; 0.25 μM(EC50)