Amino-PEG9-acid 是一种 PROTAC 连接桥，属于 PEG 类。Amino-PEG9-acid 可用于合成一系列 PROTAC 分子。Amino-PEG9-acid 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体活性分子结合物 (ADCs) 的合成。 Amino-PEG9-acid is a PEG derivative containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.