Recombinant Angiopoietin 1 Antibody

抗体

Angiopoietin 1抗体 | Angiopoietin 1重组抗体 | 血管生成素1抗体

AGP 1 antibody | AGP1 antibody | AGPT antibody | ANG 1 antibody | ANG antibody | ANG-1 antibody | ANG1 antibody | Angiopoietin-1 antibody | Angiopoietin1 antibody | ANGP1_HUMAN antibody | ANGPT 1 antibody | Angpt1 antibody | KIAA0003 antibody | OTTHUMP000

Liquid

Ab088793-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

0.02% Sodium azide

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

A synthetic peptide derived from human Angiopoietin 1 (AA 250-300).

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

Angiopoietin 1

WB: HeLa, MDA-MB-231, RAW 264.7 and C6 cell lysates.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

Whole IgG