Recombinant beta Tubulin Antibody

抗体

微管蛋白β tubulin/Tubulin β（内参）抗体 | 微管蛋白β tubulin抗体 | 微管蛋白β tubulin单克隆抗体 | 微管蛋白β tubulin重组单克隆抗体 | beta Tubulin抗体 | beta Tubulin单克隆抗体 | beta Tubulin重组单克隆抗体 | TUBB抗体 | TUBB单克隆抗体 | TUBB重组单克隆抗体

Beta 4 tubulin antibody | Beta 5 tubulin antibody | beta Ib tubulin antibody | Beta1 tubulin antibody | Class I beta tubulin antibody | M40 antibody | MGC117247antibody | MGC16435 antibody | OK/SW cl.56 antibody | OK/SWcl.56 antibody | TBB5_HUMAN antibody

Liquid

Ab091196-10μl

10μl

重组

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4.

0.02% Sodium azide

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Post-translational: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear. Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.

A synthetic peptide derived from human beta Tubulin (AA 300-360).

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

beta Tubulin

WB: MCF7, Jurkat, HeLa, A549, Hep G2, NIH/3T3 and C6 cell lysates. IHC: Human glioma, uterus cancer, Rat brain, Mouse kidney tissue. IF/ICC: NIH/3T3 cells.

150 kDa

Unconjugated

Rabbit IgG

重组抗体

kappa

Protein A purified

此产品可替代 Ab091197

Whole IgG