CBLN1 Antibody

抗体

小脑肽1抗体

CBLN 1 antibody | CBLN1 antibody | CBLN1_HUMAN antibody | CER antibody | Cerebellin 1 antibody | Cerebellin 1 precursor antibody | Cerebellin1 antibody | Precerebellin antibody | CBLN1 | [des-Ser1]-cerebellin antibody

Liquid

Ab093306-10μl

10μl

已验证

见COA

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

10mM PBS, 40% Glycerol, 0.05% Sodium azide, pH 7.4.

0.05% Sodium azide

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion. The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.

A synthetic peptide derived from human CBLN1

兔(Rabbit)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

CBLN1

WB: HUVEC, A172, RAW264.7, A549 lysates. IHC: Human tonsil, esophagus cancer tissues.

150 kDa

Unconjugated

Rabbit IgG

多克隆抗体

Antigen affinity purified

Whole IgG